Though can get through a hematoencephalic

Though can get through a hematoencephalic barrier and show central activity, its action on secretion at an acromegalia is caused by immediate influence on a tumour that it is possible to show in vitro. Reaction on , expressed in depression of level in plasma to norm, is observed approximately at 80 sick of an acromegalia [183]. Necessary doses etodolac 400mg fluctuate from 2,5 to 15 mg/sut; them enter in two steps. Sometimes note insignificant depression of arterial pressure and nausea occurrence (owing to the central effects of this substance), but in due course these symptoms, as a rule, disappear also them usually it is possible to prevent, beginning treatment from a small dose in the evening and gradually enlarging it before reception of the necessary effect. Experience of long application at several patients shows, that keeps efficiency at continuous reception within 7 years. Cancellation is accompanied by renewal of hypersecretion and consequently treatment should be continued during vaguely long time. Bromine reduces the sizes of experimentally caused tumours at rats [184], and at the person it possesses not only suppressing hormone secretion, but also antitumoral activity [185-188]. However results of its application for sufficient number of patients, use as an antitumoral agent will not be received yet should not be beyond experiment.
Thus, treatment is shown at patients at whom operation ts/ilp an irradiation or do not normalise level , or are contraindicative. It is established, that level at sick of an acromegalia acutely decreases and under the influence of blockers receptors. However therapeutic value of these agents is not known yet. THE TUMOURS COSECRETING PROLACTINUM: THE AMENORRHEA SYNDROME - GALACTORRHEAS Clinical implications tumours were known long before identification of Prolactinum as a separate hormone. A galactorrhea and an amenorrhea classified in the beginning on their development in the postnatal period (a syndrome Kiari - ) or out of it (syndrome Aumady-Del or Forbsa-Olbrajta). Long observation over patients of both these groups, especially last, has shown, that their appreciable number eventually has signs of a tumour of a pituitary body. With the advent of a radio immunologic method of definition of Prolactinum absence of a galactorrhea at appreciable number of patients with a tumour and has been established not only the high maintenance of this hormone in circulation of patients without visible signs of a tumour of a pituitary body, but also. Really, frequency of rising of level of Prolactinum voltaren cream at pituitary body adenomas fluctuates from 60 to 80 , that above, than for any another a hormone [123]. Now even more often at patients with an amenorrhea, an irregularity of menstrual cycles or sterility find inexplicable for lack of anatomic signs of a tumour of a pituitary body (idiopathic ). At usual methods of a staining pituitary body tumours often look chromophobic and for this reason the majority tumours earlier considered nonfunctioning. By means of an immunohistochemical staining almost in all these tumours it is possible to find out Prolactinum [155]. Signs and symptoms At women with note a galactorrhea, disturbances of menstrual function or sterility. For galactorrhea development, except Prolactinum, sexual steroids and consequently it is not an obligatory sign are necessary also. The galactorrhea often meets at the persons accepting peroral contraceptives, and even more often after the termination of their reception. It is considered, that galactorrhea occurrence is defined by acute depression of level of estrogen and progesterone at the persons which mammary glands "are prepared" previous by influence of sexual steroids and that occurs and in physiological conditions in the nearest postnatal period. Frequency of a galactorrhea at patients with pituitary body tumours fluctuates from 50 to 90 [189-191] and reflects degree , depending on terms of recognition of disease. The amenorrhea or oligomenorrhea meet recurrence disturbance at 60-90 of women with and almost at all women at whom radiological signs of a tumour of a pituitary body are noted. The amenorrhea can precede and on the contrary, and one symptom advances another for months or years. could interfere with normal functioning of system of a hypothalamus-pituitary body-gonad at three levels. First, Prolactinum can suppress production of progesterone cells in an ovary [192]. However ovaries at women with keep ability to react to exogenous Gonadotropinum that testifies about functions. Secondly, Prolactinum could operate in the pituitary body, braking reaction of Gonadotropinums on .