Specific pathological mechanisms

Specific pathological mechanisms of adiposity at the majority of these syndromes are unknown. However genetic change of sensitivity cells in a hypothalamus could lead to change of signals of saturation or hunger and disturbances of function buy xenical or orlistat of independent nervous system causing lipogenesis rising. Treatment of subthalamic adiposity in most cases appears unsuccessful. At children with and subthalamic infiltrates ( 8-1) remission of a basic disease under the influence of chemotherapeutic agents leads to disappearance and normalisation of mass of a body that testifies about the most important in this respect subthalamic structures. However after true destruction of separate zones of a hypothalamus functional disturbances become irreversible. Therapeutic actions at the pathological adiposity, described in one of last heads, make now unique alternative. Diencephalic syndrome at children. 70 children with an attrition and hyperkinesia syndrome at which the big size of brushes and feet sometimes becomes perceptible are described approximately; the syndrome is bound with tumours (usually ), starting with a crossroads of optic nerves or a forward hypothalamus and remaining by the moment of occurrence of symptoms within a lobby and areas [61].
Many children are recovered and cheerful, whereas others can be irritable, they keep good appetite and have normal growth. Only very much few patients were exposed to sufficient endokrinno-metabolic inspection though at some absence of circadian fluctuations of level of a hydrocortisone in plasma became perceptible, absence of reaction on and rising of level along with its paradoxical reactions on hyper-and a hypoglycaemia. The majority of children die within the first 2 years owing to attrition and complications accompanying it. At the several children, gone through the 2-year-old age, illness often undergoes sharp transformation. Appetite is enlarged, attrition disappears also children become the extremely corpulent [62]. On change of former euphoria and hyperactivity irritability and even fury attacks usually comes. The forecast for a life becomes more favorable, but it is not known, it is bound to change of a metabolism or with features of growth of a tumour [63]. Obscurely, why destruction of an unripe hypothalamus causes the symptoms differing from those at children more of advanced age and at adults. However there are the experimental data specifying that function the kernel supervising consumption maxalt side effects of nutrition, before the termination of thoracal feeding does not play an essential role. In this connection damage nonfunctioning a hypothalamus could cause rather poor semiology, and should prevail there would be effects of a hypofunction department. In process of maturing absence a hypothalamus should get the increasing clinical value and adiposity should become a leading symptom. Nervous anorexia. The nervous anorexia is known already more than 300 years as the disease shown mainly by reduction of mass of a body, an amenorrhea and the behavioural disturbances observed almost exclusively at young women. It consider as result of mental, endokrinno-metabolic disturbances or that combination and another [64]. In the past this diagnosis was put very widely to many women with an amenorrhea and , that generated appreciable difficulties in an estimation of true clinical features of disease and efficiency of its treatment. Now the majority of doctors consider, that at diagnosis statement it is necessary to consider and deviations in mentality. Illness is characterised by a number of essential features. 1. Disease begins aged more youngly 25 years, more often in an interval between 14 and 19 years. It can meet and at young men, on it is observed extremely seldom (less than in 5 of cases). 2. The diagnosis is justified only at appreciable reduction of mass of a body (not less than 25 from initial). 3. At patients the relation to meal is deformed and there is a wrong representation about ideal mass of a body that forces them to suffer hunger, not giving in on admonitions and threats. Patients deny the fact of disease and do not realise the alimentary requirements. They as though take pleasure from and refuse to accept nutrition. They consider beautiful extreme leanness and pay special attention to storage or nutrition processing. The true anorexia is shown only in late stages of disease. The most serious disturbances of alimentary behaviour observed at 50 of patients, are (superfluous consumption of nutrition) and vomiting. For patients of this group are especially characteristic a hypoglycaemia and arrhythmias. 4. Practically at all sick women there comes an amenorrhea, and at 25 of patients it precedes appreciable reduction of mass of a body. 5.