Because of insufficiency of data

Because of insufficiency of data which would allow to exclude it effect, it is recommended to stop reception as soon as it will be possible to confirm pregnancy. The main fear appearing at treatment for creation of possibility to become pregnant at women with tumours of a pituitary body, consists that at physiological augmentation of the sizes of a pituitary body during pregnancy can be enlarged and the size of a tumour that can be accompanied by its diffusion and occurrence of symptoms of a prelum of an optic chiasm. At patients without initial augmentation of a Turkish saddle such complications though meet, but it is rather rare. Unsharply expressed disturbances of fields of vision appearing at pregnancy, at the majority of patients successfully treat a conservative method, namely again use reception though some patients can purchase alli have a necessity for a surgical intervention. Application experience has shown, that it is effective at treatment of patients with remaining after an incomplete oncotomy , and it is fair both for women, and for men [199] at whom the combination and the central influences of a preparation restores Testosteron-Depotum level in plasma and a potency. it is effective, apparently, and at men with idiopathic and an impotency [220]. Preliminary obtained data testify also to its ability to stop a postnatal lactemia and to facilitate a premenstrual strain though the further clinical observations are in this respect necessary. The most important question consists in, whether possesses any antitumoral action on adenomas. Some recently published descriptions of cases and comments to them convincingly testify that can reduce not only Prolactinum level, but also the sizes of a tumour [185-188] that is shown concerning
Dofaminum agonists on model experimental tumours at rats [184]. Before it will be possible to recommend this kind of treatment, it is necessary to carry out carefully controllable research though already now it is necessary to consider such possibility (separately or a combination to an irradiation) at patients to whom the surgical oncotomy is contraindicative. it is effective and at women at whom during pregnancy has occurred diffusion of a tumour [218]. Antagonists receptors also reduce level of Prolactinum at patients with , but possibility of their application as medical agents is not studied. THE TUMOURS COSECRETING : ILLNESS The first dependence of a bilateral hyperplasia of a cortex of adrenals and clinical implications of superfluous production of Cortisonum on a pituitary body adenoma has assumed [221]. The small sizes of these tumours and a rarity from which they manage to be taped by the moment of occurrence in the patient of signs and adrenal struma symptoms, have caused concentration of attention on a cortex of adrenals as on a place of a primary lesion. However the modern data received at of operation, testify that AkTg-sekretirujushchie tumours meet almost in all cases of a hyperplasia of a cortex of buy hoodia adrenals (illness ). Occurrence of tumours of a pituitary body after a bilateral adrenalectomy concerning illness has been described for the first time Nelson and co-workers. [222], found out rising of adrenocorticotropic activity in plasma and postulating possibility of development AkTg-sekretirujushchej of a tumour owing to an adrenalectomy. At the same time the various neuroendocrinal disturbances observed at illness , and also reactions hormones on agents allow to assume a central-nervous parentage of this disease. Pituitary body tumours at illness and a syndrome of Nelson possess or basphilic (about 80 of cases), or chromophobic properties. Now it is known, that precursor with molecular mass 31000 is and that ability of tumoral cells to be painted by the basic stains is defined by presence at them of it . By means of immunohistochemical reactions maintenance can be found out both in basphilic, and in chromophobic tumours. Besides, in a tumoral tissue and blood of patients with AKTG-PRODUCING tumours presence ?-LPG and b-endorphine [31] is shown. Basphilic adenomas find in 5-7 of the pituitary bodies received at autopsy died, at which during lifetime there were no signs of hypersecretion . Not functioning tumours of this type can synthesise which never arrives in blood, and is exposed to intracellular (lysosomic) destruction, probably, because of defect of the secretory mechanism in cells of a tumour [118]. Cosecreting tumours are usually good-quality, however, unlike other tumours of a forward share of a pituitary body, can sometimes find out truly malignant properties, metastasizing both in , and out of it [223, 224].