Depression or absence of reaction meets

Depression or absence of reaction meets at adiposity, a hypothyrosis and at the patients receiving a-Methyldopa and neuroleptics. At the majority sick of an acromegalia level after reception L- decreases thanking its immediate to action on . Risk. Nausea and vomiting which are caused by stimulation mechanism Dofaminum-sensitive in concern basic by-effects L-. These complications are observed at 20-25 surveyed, usually on 2nd hour of the test and, despite small intensity, often cause moderate discomfort. Usually these symptoms disappear spontaneously, but it is possible to stop them introduction of the antagonist receptors order decadron (for example, 5 mg of Perfenazinum) after assay end. Assay with arginine infusion. L- stimulates secretion any, mediated , the mechanism. Technique. L- in a dose of 0,5 g/kg (it is maximum 30) enter a hydrochloride during 30 mines intravenously on an empty stomach in a rest condition. Blood samples for definition take on About, 30, 60, 90 and 120th minute. Not changed indicators. Usual reaction consists in rising of level not less than to 9 ng/ml, that is observed, as a rule, on 60-90th minute. At women reaction above, than at men. Interpreting of results. Usual reaction is observed at 65-75 of healthy faces. Reaction is lowered or is absent at adiposity and a hypothyrosis, and at an acromegalia varies and has no diagnostic value. Risk. In the course of test carrying out practically there are no dangers, however at patients with serious hepatic or renal insufficiency him to spend does not follow. TRG-ASSAY. A technique.
Doses and terms of sampling of blood are described in the section devoted . Not changed indicators. At healthy faces does not stimulate secretion . Interpreting of results. At 80-90 sick the acromegalia observes the sharp rising of level reaching of peak on 15-30th minute; along with the test of suppression by a glucose this assay is most useful at inspection of patients with the minimum rising of initial level . Sharply expressed reaction meets also at patients chronic renal insufficiency. At starvation, failures of a food, a nervous anorexia and a cirrhosis unlike an acromegalia reaction is late and reaches peak often on 45-60th minute. Assays on suppression of secretion Assay with glucose introduction. This test is based on suppression of secretion which occurs in norm in reply to a hyperglycaemia. Technique. Spend standard the test (75 partially hydrolyzed carbohydrates or 100 glucoses inside); blood samples for definition take before glucose reception, and also through 0,5, 1, 2 and 3 after reception. To tap a return phenomenon it is often useful to take additional blood samples on 4th and 5th hour. Not changed indicators. At healthy faces during 2 level should decrease to level more low 2 ng/ml. On 4th and 5th hour the return phenomenon and level is often observed exceeds 7 ng/ml. Interpreting of results. order avandamet This test use at inspection of patients with suspicion on an active acromegalia. At sick the acromegalia observes absence of suppression of secretion of the hormone, insufficient suppression or even its paradoxical stimulation; usual suppression of secretion excludes an acromegalia. At patients with a nervous anorexia against raised level the glucose can suppress its secretion only partially. However through the certain period of a normal food reaction to a glucose is restored. PROLACTINUM Definition of initial level Results of definition of level of Prolactinum in plasma in different laboratories , that is bound to use of different methods and standards for comparison. At use of the most cleared (NIH-VLS-2) the top border of norm at men makes of standards 15 ng/ml, and at women - 15-20 ng/ml. At children Prolactinum maintenance about same though at newborns throughout the several first weeks of a life it can reach 150 ng/ml. For an exception at the screening spent by means of unitary definitions, repeated researches as intermittent intensifying of secretion of a hormone is sometimes observed can be demanded. Prolactinum in plasma is defined at all healthy faces though in some cases its maintenance is close to border of sensitivity of a method of definition. To differentiate norm and a hypopituitarism, as a rule, it is impossible. assays The stimulus causing secretion of Prolactinum, it is possible to part on influencing a pituitary body immediately and demanding participations of a hypothalamus. Different reactions to these stimulus can promote differentiation and subthalamic disorders. TRG-ASSAY. stimulates Prolactinum secretion by not mediocre actions on by means of the mechanism bound to activation of adenylatecyclase. Technique. Doses and terms of sampling of blood are specified in the section devoted .