In the anamnesis at children with

In the anamnesis at children with this disorder very adverse conditions of a life become perceptible. At excision of the child from an adverse situation the semiology quickly disappears with simultaneous normalisation of secretion . Assume, that one of causal factors at the given syndrome is excessive intensifying ?-adrenergic brake effects. In the literature there is a report on normalisation of secretion by means of acute introduction of propranolol () [40]. Chapter 9. DISEASES of the BACK SHARE of the PITUITARY BODY G.L.ROBERTSON (G. L. ROBERTSON) HORMONES OF THE BACK SHARE OF THE PITUITARY BODY ANATOMY The neurohypophysis represents the extended diverticulum of a ventral hypothalamus voltaren xr immediately contacting to a back and distal part [I]. At adult men and women the neurohypophysis mass makes approximately 100 mg, and it can be parted on two parts bridged by a short leg, passing through a diaphragm of a Turkish saddle. The top part name variously: a funnel or a median eminence, and bottom - a process or pars nervosa. Both parts are supplied with blood from branches top and bottom the arteries departing from back and an intracavernous part of internal carotids. In pars nervosa arterioles break up to local capillary networks which are drained immediately in a bulbar vein through venous sine (a Turkish saddle, cavernous and lateral). In a funnel primary capillary networks merge in another si - Under a microscope the neurohypophysis looks as densely bound network of capillaries, pituicytes and nervous in-lolon, elektronno-dense granules containing the big number. These neurosecretory neurones originate mainly in macrocellular kernels and areas of a hypothalamus [2].
The majority of axons is referred from here ventrally and caudally and terminates in expansions on the capillary networks penetrating all parts of a neurohypophysis, including a leg and a funnel ( 9-1). Last serves as a place of the termination and other neurosecretory neurones influencing a forward share of a pituitary body, by liberation of stimulating or braking factors in portal veins. Whether play a similar role funnel neurones - it is not known. There is also special still a smaller department of a neurohypophysis which is projected on III and, possibly, lateral ventricles of a brain [1, ]. Apparently, from it the secret, is allocated immediately in , but is definitive its function is not established [4]. CHEMISTRY It is unique the known hormones cosecreted by a neurohypophysis of the adult person, the vasopressin and Oxytocinum are. Their structure has been deciphered for the first time du Vigneaud with . More 20 years ago [5]. Each of these hormones the group in which (represents , consisting of a ring closed by a disulfide etodolac 400 ponticulus, and a trailer part, terminal 9-2). The vasopressin differs from Oxytocinum only presence on Isoleucinum place in a ring and an arginine on Leucinum place in a trailer part of a molecule. These two hormones are found out in all mammals, except for suborder Suina at which some kinds the variant of a vasopressin containing in 8th position a lysine instead of an arginine [6] is formed. Oxytocinum is found out also in many kinds of birds, reptiles, amphibians and bony fishes. However instead of a vasopressin the pituitary body , not belonging to the class mammals, contains . Its structure differs from vasopressin structure only presence at 3rd position of Isoleucinum, and biological effects of both bonds are identical. As is unique a hormone found at some ancient , it consider as the precursor of whom in the course of evolution owing to a mutation and doubling of genes Oxytocinum and a vasopressin were formed. Synthesis of the big number of structural analogues of a vasopressin and Oxytocinum has allowed to find out more precisely dependence between their conformstion and biological activity [7]. Though change almost any part of a molecule can affect three-dimensional structure and biological activity, as the most important for a recognition and hormone linkage by its receptor consider lateral chains in 3, 4, 7 and 8th position whereas replacements in 5th position influence own activity of a molecule. At replacement in 8th position of a L-arginine on a D-arginine the relation of antidiuretic effect of a vasopressin to it activity is sharply enlarged. This updating along with excision of a terminal amino group of Cysteinum forms the 1-1-1-1-1-vasopressin () ( 9-2 see) - clinically applied analogue possessing longer and strong antidiuretic activity [8]. The vasopressin and Oxytocinum are postponed in a neurohypophysis in the form of insoluble complexes with the fibers-carriers which have received the name .