and at girls - a primary amenorrhea

and at girls - a primary amenorrhea. At some children deficiency and others hormones besides owing to a subthalamic pathology develops. Night liftings of level in the plasma, appearing in norm in the period, are absent; clinically this disease is similar with a primary hypopituitarism. Characteristic symptom at some boys with a hypogonadotrophic hypogonadism is the anosmia or a hyposmia. These symptoms form syndrome or an olfaktorno-genital dysplasia which can be accompanied by other neurologic disturbances, tegretol xr such, as colour blindness and deafness owing to a lesion of an acoustical nerve. Usually this syndrome has the hereditary nature [32] though sporadic cases of disease are described also. At some patients meets, besides, depression of sensitivity of spermaries to . In some cases [33] the hypothalamus hypoplasia, no less than a hypoplasia of area of a lobby and olfactory bulbs is observed. Value of olfactory stimulus in regulation of sexual behaviour of the lowest mammals of both sexes and recurrence of secretion of Gonadotropinums females well-known, and have data about a role of olfactory stimulus in regulation of secretion of Gonadotropinums and for primacies [34] and even at the person [35]. At such patients reaction of Gonadotropinums to unitary injection LG-RG is considerably broken or is absent, that specifies in insufficiency of previous (endogenous) stimulation from party LG-RG.
If repeated introduction LG-RG leads to "emission" of Gonadotropinums normal or even excessive reaction eventually is observed; in such a way it is possible to distinguish this condition from a primary hypopituitarism. Treatment consists now in application of sexual steroids for maintenance of development and conservation of secondary sexual signs and introduction of Gonadotropinums for fecundity maintenance. Preliminary results of application of analogues LG-RG promise, however, possibility of more physiological approach to treatment of this condition in the future. the subthalamic hypogonadism meets mainly at women. Usually it is shown by a secondary amenorrhea and sometimes the sterility bound with of cycles. Widely used term "functional", or "psychogenic", the amenorrhea means, apparently, the same condition. At patients level of estrogens can decrease; the egestion of Gonadotropinums with urine remains in norm, judging by results of definition by means of a biological method; level and in Serum appears low in relation to the lowered level of Oestradiolum [36]. Pulsing fluctuations of level in Serum, characteristic for healthy women, at the majority of patients are absent. After unitary injection LG-RG the augmentation of level quantitatively often exceeding norm and in Serum order zanaflex is observed qualitatively not changed, but. In norm reaction and to introduction usually remains. These data testify to functional disturbances of subthalamic mechanisms of secretion of the rilizing-factor. The secondary amenorrhea usually disappears spontaneously. Similar physiological disturbances are observed at women with irrespective of its aetiology (i.e. Postnatal, idiopathic, tumoral, uremic). Data of the numerous researches spent at women with not physiological , testify that reactions on remain, but reactions to Oestradiolum disappear [37], that speaks well for selective influence on effect of Oestradiolum on the mechanism of the positive feedback, becoming isolated in . In a postmenopause at women with level and raises, that serves as the additional proof of conservation of the mechanism of a negative feedback. Now it is not clear, whether are disturbances in a hypothalamus a specific consequence or changes of secretion of Gonadotropinums and Prolactinum are defined by disturbances mechanisms. At men it is accompanied by a hypogonadism of various degree, and the most frequent symptoms are depression and potencies. The amenorrhea often accompanies change of mass of a body (both its sharp augmentation, and depression). This condition is rather extended at ballerinas and sportswomen and meets almost in 100 of cases at a nervous anorexia. The hypogonadism is combined also with other diseases for which signs of dysfunction are characteristic, and character of pathology and the hypogonadism reason in these cases remain unknown persons. Lawrence's syndromes concern such conditions - Moon, the Bard - and - which-have also other similar lines, more in detail they are surveyed in this chapter further. Planned treatment depends on character of primary disease and its convertibility, degree of a hypogonadism and desire of patients to have children. Whenever possible it is necessary to try to liquidate the basic pathological process. Radicalism and urgency of therapeutic actions should be defined by gravity of semiology. At the majority of the women who are not aspiring to restoration of menstrual function and-or pregnancy, treatment is not required.