Proceeding from the given observations

Proceeding from the given observations, according to which the agents breaking transfer in nervous system (antagonists especially possessing antipsychotic properties receptors), raise Prolactinum secretion, see a cause of illness in dynamics disturbance in . However at chronic introduction of neuroleptics Prolactinum level seldom exceeds 100 ng/ml, and these agents operate not only on , but also on a pituitary body. Clinical implications idiopathic are similar to symptoms of other forms and include a galactorrhea and an amenorrhea. Treatment maxalt rpd depends on subjective sensations and intentions of each separate patient. (usually 2,5 mg twice a day) reduce Prolactinum level, liquidates a galactorrhea and restores a menstrual cycle and a fecundity [44]. Almost at 80 of patients of a menses are restored during 2 after the treatment beginning. However this substance operates shortly and renews already through 48 after its cancellation. The most important place of the appendix of action is the pituitary body where it is bound by receptors. can operate also on a tract of a hypothalamus which takes part in regulation of secretion of Prolactinum. It is not known yet, whether normalises long treatment secretory dynamics of Prolactinum. The galactorrhea can meet also for lack of menstrual disturbances and against normal level of Prolactinum: in its such cases charge to a hypersensibility: to endogenous Prolactinum, it is possible owing to quantity or affinity augmentation receptors in mammary glands. Suppression of secretion of Prolactinum , as a rule, eliminates a galactorrhea and in these cases. Like it, at some women with an amenorrhea treatment restores a menstrual cycle; it is supposed, that as the reason of this condition rising of sensitivity to Prolactinum action on effect of estrogens on a feedback mechanism serves. Vasopressin (antidiuretic hormone) it is in detail surveyed in the following chapter.
This section is devoted conditions of a so-called cerebral hyponatremia and a hypernatremia, caused or organic damages , or medicinal therapy. Hyponatremia. The syndrome of inadequate secretion of an antidiuretic hormone () meets not only at ectopic production cancer tumours, but also at the various pathological conditions involving in process as , and peripheric nervous system [45]. Cancer metastasises concern them in a brain, primary tumours of a brain, fractures of base of the skull, cerebral , a brain infarct, a subarachnoidal hemorrhage, a meningitis, an encephalitis and an acute intermittent porphyria. In all descriptions of cases criteria of the diagnosis of inadequate secretion are observed: the hyponatremia, sodium loss through kidneys, conservation in norm of function of kidneys, a pituitary body, thyroid and epinephral reductil sibutramin meridia xenical orlistat glands, disability to excrete divorced urine after a water load, resistance to corrective action of a hypertensive saline solution and convertibility of changes under the influence of restriction of consumption of a liquid. In some cases low level of sodium in Serum is accompanied by cerebral symptoms and changes on which disappear after hyponatremia liquidation. At other patients in most cases it is possible to explain clinical implications by the basic organic disease. The raised egestion of sodium is, apparently, a consequence of augmentation of extracellular volume of the liquid caused by inadequate secretion , that in turn can suppress Aldosteronum secretion. In plasma of patients with this syndrome the raised maintenance immunoreactive is revealed . Apparently, at different patients the semiology is defined by different mechanisms (change-over of osmoreceptors, constant "efflux" , peripheric resistance, casual "flashes" of secretion ) [46]. hormones can normalise negative balance of sodium, but not disturbances which with the big success give in to treatment by restriction of consumption of a liquid. Some and antitumoral preparations cause a hyponatremia. Chlorproramidum, Tolbutamidum (Butamidum) concern the first and is more rare . Vincristinum and cyclophosphamide (Cyclophosphanum) concern antitumoral agents. Carbamazepine (Tegretolum), amitriptyline (Elavilum), Thioridazinum (Mellarilum) and can cause a hyponatremia also. If agents strengthen action on renal canaliculuses and, besides, possibly, stimulate secretion Vincristinum as it is established on rats, possesses immediate action on a neurohypophysis therefore allocation amplifies a little. , apparently, also liberates endogenous [47]. Hypernatremia. There are numerous reports on a hypernatremia at patients intracranial damages, especially at serious disorders of consciousness or a clod. The hypernatremia grows out of introduction of strong solutions or disturbance of normal consumption of a liquid.