For example, changes of a circadian

For example, changes of a circadian rhythm of level of a hydrocortisone in plasma often observe at patients with a lesion of a hypothalamus or limbic system (whence through a hypothalamus there are the ways regulating secretion ), but meet at a lesion of other areas [22] less often. At patients with hypothalamus tumours reactions on [23, 24] often change, that specifies in loss of a subthalamic feedback mechanism though change of these reactions does not correlate with changes of a circadian rhythm. Further the clinical syndromes bound to subthalamic disturbances of secretion rilizing - or inhibiting factors are surveyed. It is necessary what is the difference between soma and robaxin to underline, however, that in many of examples there are no proofs of a subthalamic pathology. a hormone Subthalamic, or tertiary, the hypothyrosis represents the disease characterised by a hypothyrosis, low maintenance in plasma and the strengthened or late reaction on tirotropin-rilizing a hormone (). At the majority of healthy faces the peak of level after introduction is registered on 15-30th minute [25]. In one of groups of children which as considered, suffered a tertiary hypothyrosis, level , but reaction on have been found out slightly raised in comparison with initial it has appeared shifted in time [26]. The subthalamic hypothyrosis can be shown as the isolated disease, but at children it is more often accompanied by insufficiency of secretion of Gonadotropinums, and-or . Frequency of subthalamic disorders as the hypothyrosis reason is unknown, but, possibly, is low enough. The majority of patients does not have signs of disturbances of other functions .
Corticotropin For insufficiently clear reasons depression of secretion owing to pathological changes in a hypothalamus or other departments TSNS meets less often, than depression of secretion of other hormones of a forward share of a pituitary body. It can be implication of the isolated disturbance or to be combined with disturbance of secretion of other hormones of a forward share of a pituitary body (usually at children). Owing to absence of possibility of use factor Adrenocorticotrophinum-rilizing cannot be differentiated with definiteness and a subthalamic genesis of this disease. However not changed reaction hormones on LG-RG and at children with an idiopathic hypopituitarism allows to assume a subthalamic genesis of insufficiency . At patients with various intracranial diseases the daily rhythm of secretion against conservation of its reaction to braking influence is often broken; it reflects early stages of insufficiency neuroendocrinal mechanisms. To such disturbances do not give the big clinical value, but it is impossible to exclude skelaxin medication possibilities of their influences on behaviour. The aetiology of illness still remains an unresolved problem. It is possible to assume, that the majority of the disturbances observed at patients (loss of circadian periodicity of level of corticosteroids, absence of reaction of their level in plasma on stress, absence of depression of their level under the influence of dexamethasone, disturbance of reactance and changes on during a dream), speaks functional changes of subthalamic mechanisms of regulation of periodicity, sensitivity to stress and "threshold" of suppression of secretion of steroids [27]. There are separate descriptions of cases of a combination of illness intracranial diseases [28] though now it is impossible to exclude thus ectopic production . The syndrome of periodic hypersecretion along with rising of its maintenance in plasma and insusceptibility to dexamethasone at which expansion of ventricles of a brain with an atrophy of a cortex [29] was a unique positive neurologic find is described. Similar changes found at autopsy at died as a result of classical illness [30]. In favour of a central-nervous genesis of this disease it is possible to treat and reaction of some sick of illness on treatment by cyproheptadine (which as consider, operates through the mechanism) [31] as it is supposed, that this substance influences on hypothalamus receptors, instead of a pituitary body. Can quite be, that exists not less than two forms of illness , one of which develops owing to excessive subthalamic stimulation, and the second is defined by a primary microadenoma of a pituitary body (see chapter 7). Clinically to part these two possible forms now it is impossible. Luteinizing and follicle-stimulating hormones Subthalamic hypogonadism define as disturbance of function of a pituitary body and sexual glands owing to insufficiency or broken secretion LG-RG. This condition can meet at a destruction of a hypothalamus or in the absence of pathological changes. Its implications vary depending on that, there are they prior to the beginning the period or after it. the subthalamic hypogonadism causes absence of normal puberty