To possess

To possess so specialised and functions, fibers as a result of evolution of the genes defining their amino-acid sequence, should get that structure which they have now. Other genes coding synthesis of products take part in some cases in process, modifying fibers (for example, by ) also. As evolution of genes, apparently, occurred at the expense buy cheap cipro of such mechanisms as a mutation of preexisting genes and a recombination of sites of various genes (about what it was spoken), it has imposed certain restrictions on fiber evolution. From the evolutionary point of view, possibly, it would be easier to alter present structures, than to frame absolutely new genes. In this connection existence of some in amino-acid sequences of various fibers can and not to be unexpectedness as their genes could arise owing to evolution of the general precursors. As, as it became perceptible above, the sites of fibers fitted for linkage , such as and steroids or their analogues, already should exist by time of occurrence of these , easily imagine, as updating of genes of such fibers can lead to synthesis of other fibers keeping high specificity of linkage . On 2-2 one of hypothetical schemes of evolution primitive in three existing type fibers is resulted: bacteriemic tsamf-binding fiber (CAP or CRP), regulating a transcription of the several genes coding enzymes which take part in a metabolism of lactose [4], and also tsamf-binding fiber of mammals which regulates activity of the tsamf-dependent protein kinase mediating action at the person (see chapter 4), and adenylatecyclase (see chapter 4).
With reference to bacteriemic fiber and ATF-BINDING sites of a primitive glucokinase evolved in a direction of acquisition of larger specificity of linkage . Bacteriemic fiber has got also additional a polynucleotide (DNA)-binding ability. Evolution assumes acquisition abilities fibers. At last, of a glucokinase by replacement of ADF-GENERATING function on tsamf-generating it could be formed and adenylatecyclase. These conclusions should be especially hypothetical; nevertheless they show, how molecular evolution listed fibers could be carried out. Though many details in a picture of evolution of fibers are absent, data available now on structure of fibers and genes give some bases for the analysis of a question on, whether there were genes of some polypeptide hormones from the general gene-precursor [5]. Separate polypeptide hormones can be grouped on structural similarity. There is nothing surprising that the hormones concerning one group, can possess and similarity of physiological effects caused by them, and also the similar mechanism of action. So, a growth hormone (), Prolactinum and chorionic (a placental lactogen) are characterised by high degree amino-acid sequence. hormones - a hormone (), chorionic Gonadotropinum of the person (), follicle-stimulating () and luteinizing () hormones - consist of two , everyone, one of which (A-chain) is identical or nearly so is identical at all hormones of the given group [4]. The amino-acid sequence In in various hormones though it is not identical, but buy rimonabant acomplia has structural . Possibly, these differences of V-chains have crucial importance for giving of specificity to interaction of each hormone with its target tissue. Insulin finds out some structural analogues and possesses the general biological activity with other factors of growth, such, as and not suppressed insulinoid activity () [6]. As to group of hormones to which the growth hormone the sequence , coding their synthesis, is found partially out [5] belongs. Three nucleotides are necessary For each amino acid in DNA (and, hence, in transcribed with it ). Though to the given triplet of nucleotides; (Codonum) corresponds the given amino acid, for the same amino acid there can be some Codonums. Such a genetic code causes possibility larger or smaller sequences of two given genes defining structure of two hormones, than is available in fibers. So, if two fibers possess casual amino-acid sequence sequences of nucleic acids could find out the big differences. However concerning the genes coding synthesis of hormones of group of Somatotropinum, it not so; sequences of nucleic acids above, than amino-acid sequence [5]. And chorionic which have 87 amino-acid sequences, in the 93 sequences of nucleic acids have a hormone of growth of the person. Hormones of growth of the person and a rat possess 70 amino-acid sequences, and them 75 find out sequences of nucleic acids. In some sites a hormone of growth of a rat and chorionic the person ( two different hormones at two biological kinds) 85 (make 2-3).