There are reports on presence

There are reports on presence in urine that followed expect, as approximately 15 entered quickly get to urine in not changed kind. However methodical difficulties of radio immunologic definition bring up a question on, whether the substance really found out in urine is . Recently carried out researches by means of affine on with anti-TrG IgG have shown a chromatography, that practically all immunoreactivity] earlier defined in urine, buy decadron is caused not . The digits received by means of this method, were much below received in other laboratories by the direct radio immunologic analysis, urine though the percent of detection added to urine made only 35. These results testify that the endogenous immunoreactivity] defined in urine of the person, can be caused presence not most , and the substances giving two-dimensional reaction with antibodies to this hormone. HORMONES WITH THE FOUND OUT STRUCTURE For last decade three factors have been allocated and in detail characterised: tirotropin-rilizing a hormone (), gonadotropin-rilizing a hormone () and a hormone inhibiting liberation of a hormone of growth (). They have the following structure a hypothalamus Deafferentation reduces concentration only in him, but not in other departments of a brain; it testifies that extrahypothalamic is formed not as a result of activity of neurosecretory cells of a hypothalamus. The reason of depression of level in a hypothalamus after such deafferentation remains obscure. Consider, that this depression is caused or the termination of stimulating nervous influences on subthalamic TRG-PRODUCING cells, or a section of the axons bringing from areas, located out of a hypothalamus, or, at last, by possible disturbance of circulation of a spinal liquid, that also interferes with transport from extrahypothalamic areas in a hypothalamus.
Despite depression of maintenance in a hypothalamus, at animals normal reactions to introduction of a propylthiouracil and or influence remain. The reactions remaining at animals, transferred a hypothalamus deafferentation, decrease at electrolytic destruction of a median eminence. Apparently, in the field of an arched kernel and a median eminence there is stock which in conditions functions of cells of a pituitary body can provide conservation of a feedback and reactance of a pituitary body. Believe, that the mechanism of action on a pituitary body consists in activation of system adenylatecyclase-tsamf. This effect is blocked by thyroid hormones by synthesis the fiber interfering implication of action . Corticosteroids which, possibly, reduce secretion , also block also its stimulating action on secretion . As to Prolactinum buy avandamet corticosteroids do not reduce its reaction on , and the thyroxine reduces this reaction only partially. also blocks reaction , but not Prolactinum, on . Similarity of effects of a thyroxine, Cortisonum and means, that or two types of cells (i.e. and ) possess unequal receptors to , or these effects are carried out not at receptor level. Introduction L-dofa blocks reaction on as , and Prolactinum. At patients with real or prospective tumours of a pituitary body, i.e. At an acromegalia or illness (but not at healthy faces), influences secretion accordingly a hormone of growth and . suppresses rising of level of a hormone of growth in plasma at night, and at animals intraventricular introduction brakes rising of level of a hormone of growth in the plasma, caused by pharmacological agents. It is considered, that in conditions ways influences them, oppressing stimulating action on secretion . At disturbance of function of these ways (that, possibly, it is observed at an acromegalia) can immediately influence a pituitary body, raising secretion . In the same way, can stimulate secretion only at integrity disturbance (anatomic or functional) communications in . As to mentioned behavioural effects its definition in a brain primitive which do not have pituitary body or a thyroid gland, corresponds to possibility of direct influence on function . The first data about "softening" of depressions at introduction have not been confirmed. However shortens duration a narcosis, behavioural effects of Dofaminum and a serotonin and enlarges LD50 , reducing thus LD50 strychnine. These data will be compounded with representations about exciting action on . Recently obtained data of electrophysiological researches testify to possible participation in inhibition of flashes of activity of certain population of subthalamic cells. Behavioural effects can be defined not only its action on nervous cells (to what researches with a microionophoresis), but also change of a circuit of transmitters (for example testify, Noradrenalinum) in a brain. Acceleration of a circuit of Noradrenalinum in a brain cortex was observed at the rats receiving .