Though the mechanism

Though the mechanism including activation , can reflect the general property secretory cells, at hormonal stimulation of specific cells-targets other stages of a metabolism vary also. So, in cells of a granuloma of an ovary where enlarges production of Prostaglandinums, the hormone does not raise formation of arachidonic acid, and operates order buy ultram online at later stages, enlarging activity [63]. This effect of L on synthesis of Prostaglandinums in a follicle (bubbly a follicle), apparently, does not mediate Gonadotropinum action, but plays the important role in development of an ovulation [64]. Circuit stimulation and formations . make small, but the important part a plasmatic membrane in the majority cells. Main a lipid in the majority of cells is () in which it is attached to to phosphatic group a skeleton. (di - and ), containing mono-or twice hydroxylic groups , are present at a plasmatic membrane in smaller quantities. turn each other under the influence of ATF-DEPENDENT and and are blasted to and . Within several years it is known, that at stimulation of secretory cells metabolism with augmentation of including of radioactive Natrii phosphas and in and its precursor amplifies. Now it is established, that this reaction reflects disintegration and resynthesis and as postulated Nichell [65], is the general consequence of interaction between and receptors of a cellular surface.
Later it was found out, that this reaction characterises the interactions leading to rising of intracellular concentration of calcium. Reaction often does not depend on extracellular and intracellular concentration of calcium and it is represented the general process accompanying activation of receptors, leading to inflow or mobilisation of calcium and rising of its concentration in cytoashes. From here the assumption has been made, that disintegration takes part in the general mechanism with which help activation of receptors of a cellular surface supervises mobilisation of calcium [65]. Rising of concentration of calcium in a cytoplasma could be defined by augmentation of permeability of a plasmatic membrane vpxl work or liberation of calcium from stocks in a plasmatic membrane or mitochondrions. Till now in tissues stimulated with hormones noted distinct correlation between reaction and calcium mobilisation. Unlike it it has been shown, that some hormones which raise intracellular level , but not calcium, practically do not influence a metabolism . Thus, reaction it is not simple the general answer of cells to activation of their superficial receptors, but, apparently, prominent feature of stimulus for which calcium mobilisation is an essential component of reaction of cells-targets [65]. Additional feature the interactions causing reaction , is activity rising and cGMP level in a cell. As, it already became perceptible, possibly, represents a consequence of rising of intracellular concentration of calcium, instead of a necessary stage of process of activation which causes characteristic reaction of a cell-target to hormonal stimulation. Though between reaction and calcium mobilisation at activation of many cellular receptors for certain there is a close interface, the communication nature between these processes is not clear yet. Most likely, receptors of circuit occurs in a plasmatic membrane of a cell therefore permeability for calcium and-or calcium liberation in a cytoplasma is enlarged. Disintegration stimulated with a hormone could be the important component of some mechanisms bound to activation of receptors, causing opening of calcium channels on a cellular surface, and also modulating effects of other receptors which activate adenylatecyclase [65]. Other prominent aspect of metabolism is bound to a possible role in operation hormones. These strongly charged lipids are exposed to a fast metabolic circuit, especially in a brain, and accelerate the disintegration at stimulation a-adrenergic and receptors. Unlike reaction , these changes depend on level of calcium and can represent secondary answers to rising of its concentration in cytoashes like the general change of activity [28]. The potential role in operation hormones is established for a cortex of adrenals in which acutely raises the maintenance difosfo . These effects are reproduced and , and, as well as effects , they are blocked by inhibitors of synthesis of fiber. Addition to adrenal mitochondrions or the isolated cells raises production and Corticosteronum that testifies to a mediating role in steroidogenesis stimulation in adrenals under the influence of and [66]. Methylation stimulation . Synthesis from in a cellular membrane passes through two consecutive stages of the methylation, carried out by carrying over groups with S-adenozilmetionina under the control of two enzymes named I and II. The first enzyme transfers one group, forming ; both substrate , and the first enzyme are localised on the cytoplasmatic party of a cellular membrane. The second enzyme transfers two more groups besides with S-adenozilmetionina, forming . Both a product , and the second methyltransferase settle down on an external surface of a membrane. Such azygomorphous distribution of enzymes and their substrates promotes fast carrying over through a plasmatic membrane during a consecutive methylation .