SYNTHESIS AND METABOLISM

SYNTHESIS AND METABOLISM Concerning synthesis and a metabolism various it is known very much. Data about capture of specific amino-acid precursors , about enzymatic synthesis, about accumulation in special granules which protect from destruction, about allocation of such granules under the influence of the stimulus causing of a neurone, about interaction allocated with receptors on a neurone (for example, receptors on the neurosecretory cell containing order what is ultram a hormone) and about a metabolism free , not co-operating with a receptor, or by repeated absorption in the presynaptic nervous termination, or by extracellular transformation into biologically inactive products are obtained. On 6-6 the main things in and enzymes of their synthesis and disintegration are presented. On 6-7 this process with reference to to a cell and influence on it various agents is represented. NEJROFARMAKOLOGICHESKY EFFECTS There is a big number of points in which pharmacological agents can influence on function and, hence, on allocation hormones. Some agents find therapeutic application at not endocrine diseases, therefore it is important to know their collateral endocrine action; other preparations are applied in experiment to finding-out of the various parties regulations.
Some of effects of pharmacological agents for secretion of hormones are summarised in tab. 6-3. Comparison of the resulted data with given tab. 6-2 should specify in mechanisms of action concerning function of a forward share of a pituitary body; so, the substance considerably raising concentration of a serotonin, should activate secretion of a hormone of growth and Prolactinum. As some agents influence some transmitters at once, their hormonal effect should be a resultant of these influences. On an example of each of these substances it is possible to show the difficulties meeting at the characteristic of effects of hormones. Concerning it was found out, that it influences secretion not only one a hormone; its introduction causes secretion as , and Prolactinum. In this connection there was a question, whether is identical prolaktin-rilizing to a hormone (), or nevertheless there is the special factor regulating secretion of Prolactinum (see further). It is necessary to notice, that terms "factor" and "hormone" in this case are interchangeable, though factors usually name substance with yet not found out chemical structure. Besides, not only stimulates secretion , but also causes behavioural reactions which can be observed and at animals. With the advent of new techniques identifications hormones the substance with an immunoreactivity] similar , was revealed in many departments TSNS (see further) that has pyridium 100mg allowed to replace the former term subthalamic hormones on hormones. Similar data are available and concerning . This hormone (see further) liberates both , and and consequently till now is not clear, whether there are separate rilizing-hormones for each of these hormones. Similarly , presence was revealed and out of a hypothalamus; also possesses the behavioural effects remaining for lack of a pituitary body. was the first identified the factor oppressing liberation of a hormone. Its concentration in hypothalamus extracts is usually enough great to disguise possible presence of the rilizing-factor of a hormone of growth. Detection in peripheric nervous system, a pancreas and in cells of a gastroenteric tract confuses a problem factors even more. It is shown, besides, that inhibits secretion not only a growth hormone, but insulin, a glucagon and Gastrinum. TIROTROPIN-RILIZING THE HORMONE () Representing tripeptide was the first of the identified hormones. Its distribution, according to the radio immunologic analysis, is presented to tab. 6-1. Though its quantities found out of a hypothalamus also are insignificant, but they become appreciable if to consider, that the mass of a hypothalamus at a rat makes only 1/100 from a brain lump. In this connection on a share extrahypothalamic 80 from its general maintenance in a brain are necessary almost. it is synthesised it is artificial and it is widely applied in the experimental and clinical purposes. A number of its analogues to find out communication between structure and activity is synthesised also, and also to receive antagonists or derivatives with larger duration of action. The period of semilife in blood of the person makes approximately 4 minutes It quickly is inactivated in plasma by thermolabile enzymes and consequently at definition of concentration in blood important to inactivate these enzymes. In peripheric blood of a rat concentration makes about 40 pg/ml, but in a blood plasma of portal system of a pituitary body it above [3]. At the rats subjected to cooling either receiving a thyroxine or a propylthiouracil, it was not revealed changes of concentration in plasma though all these influences change the maintenance in plasma [4]. Like it, maintenance and in a brain or a hypothalamus of rats in the conditions of a thyroidectomy introductions 4, a-methyl-R-Thyrosinum or r-hlorfenilalanina did not change.