So, ?-receptor antagonists

So, ?-receptor antagonists (for example, propranolol) strengthen, and a-receptor antagonists (for example, Phentolaminum) suppress action of various stimulus. However the majority applied in. antagonists of receptors forces to concern with care interpreting of separate results. Dofaminergichesky receptors are mediated cheap levitra by stimulating influences, and such agents as L-dofa (the nearest precursor of Dofaminum), Apomorphinum and (an agonist receptors), stimulate, whereas Chlorpromazinum (aminazine) and Pimozidum (antagonists receptors) interfere with reactions to numerous stimulus. Serotoninergichesky receptors also mediate stimulating metabolic signals, and is possible, and the signals causing secretion , bound to a dream though on this question still there are disagreements. In regulation of secretion bound to a dream participate, apparently, and cholinergic mechanisms. Analogues of an enkephalin stimulate secretion [76], but the role of endogenous enkephalins in regulation of secretion of this hormone is not clear yet. Besides, there are data about stimulating influence on its secretion of GAMK-ERGICHESKY neurones [77]. PROLACTINUM Action As the basic target of action of Prolactinum the mammary gland where it stimulates development of a specific tissue and a lactemia in a combination to other hormones serves. Prolactinum is necessary buy decadron online for normal development of mammary glands in animal many kinds, but in the person its importance in this respect is not established yet. The pathological augmentation of secretion of Prolactinum usually is not accompanied by augmentation of the sizes of mammary glands, and at men the gynecomastia develops against normal level of Prolactinum. During pregnancy Prolactinum in a combination to estrogens, progesterone and a placental lactogen and in the presence of insulin and a hydrocortisone provides the further development of mammary glands that leads eventually to milk development. Prolactinum specifically stimulates synthesis of fibers, including , and also Adepses and milk carbohydrates. In an intact tissue of a mammary gland receptors of Prolactinum which are localised on alveolar surfaces of cells have been found and partially characterised. Prolactinum receptors are taped also in a tissue of a liver and kidneys, and Prolactinum, apparently, can enlarge number of own receptors. The beginning of a lactemia after sorts is caused by sharp depression of level of estrogens and progesterone of a placental parentage. Really, estrogens, being synergists of Prolactinum concerning stimulation of development of mammary glands, simultaneously are its antagonists concerning influence on a lactemia. This phenomenon forms a basis of application of estrogens for lactemia oppression in the postnatal period, and also explains frequent occurrence of a galactorrhea in women with after the termination of reception of oral contraceptives. For maintenance of the begun lactemia continuous secretion of Prolactinum is required. Its inhibition by means of pharmacological or surgical agents leads to the lactemia termination. The secretion of Prolactinum stimulated with the certificate of a suction, during the postnatal period gradually decreases to normal level. However the true reflex of "emission" of milk is mediated not by Prolactinum, and secretion of Oxytocinum by a back share of a pituitary body. Oxytocinum causes reduction cells round terminal acinar lobes which push out milk containing in them in ducts between lobes. At rats Prolactinum is necessary for maintenance of secretory activity of a yellow body and consequently plays a role in pregnancy conservation its early stages. At the person this effect, apparently, is not obligatory though for production of progesterone cells the person small amounts of Prolactinum [78] nevertheless are necessary. Its high level, on the contrary, causes progressing inhibition of secretion of progesterone. Prolactinum together with and is present at a follicular liquid, and there are data according to which it can block stimulating influence on secretion of estrogens developing a blister. Besides the influence on physiology of genesial system, Prolactinum at animal some kinds an effect has on behaviour, and also on a vodno-ELECTROLYTIC exchange though concerning the person data about similar effects are not too convincing yet. At birds and mice Prolactinum strengthens implications of a maternal instinct that plays an essential role in life cycle of these kinds. Though at the person the raised level of Prolactinum accompanies many mental sensations (see further), intensifying of secretion of a hormone is, apparently, a consequence, instead of the reason of such sensations.