Metabolism

Last is shown by disturbance of an albuminous metabolism, a proteolysis and accumulation in liquid mediums of an organism of middlemolecular uremic and other order Glucosamine Sulfate fibers against a depression of function natural organism systems.
Disturbances of water-salt balance join it. Increase of this status leads to a lethal outcome and consequently demands emergency therapy. The lethal outcome comes in of cases of a Lyell's disease. Clinical picture. Children and adults young and middle age are ill mainly.
Disease develops usually acutely, quickly resulting the patient (within several hours or 1-3 days) in serious and extremely a grave condition. The body temperature suddenly rises to on a skin of a trunk, extremities, the person arises plentiful an eruption in the form of nasyshchenno-red colour of hydropic maculae which, "spreading", form the confluent centres of a lesion. In some hours (to 48) on the inflamed skin plural bubbles of the various sizes (to a palm in size) with the thin, flabby, easily broken off tyre cover baring extensive painful, easily bleeding erosions are formed. Soon all skin takes a form scalded (reminding a combustion of II degree).
It it is diffusive , it is painful; The false skin easily moves at a touch, there are symptoms of "the moistened linen (the false skin under a finger moves, slips and it is wrinkled), symptoms of "glove", "socks" (the false skin exfoliates, keeping the form of fingers, a foot). Nikolsky's symptom sharply positive. It is possible also an eruption. On buy cialis generic online oral cavity mucosas, labiums there are extensive plural erosive sites, painful, easily bleeding, on labiums they become covered by hemorrhagic crusts and the cracks complicating food intake.
Mucosas of a pharynx, a larynx, a trachea, bronchuses, a digestive tube, an urethra, a bladder can be involved in process. The mucosa of genitals, and also eyes with development erosive , an iridocyclitis is often amazed. process on a skin and mucosas is characterised by a necrosis of a false skin with formation of subepidermal and intraepidermal bubbles and full loss of structure of all layers of a false skin. Contents of bubbles sterile.
The derma is hydropic, the infiltrate round vessels and glands small and consists of lymphocytes with an impurity of neutrophils and plasmocytes. An epithelium of capillaries bulked up. The general condition of the patient quickly worsens to degree of the extreme gravity shown by a heat, headaches, prostration, drowsiness, symptoms of dehydration of an organism (excruciating thirst, dropping of secretion of glands of a digestive tube, a pachemia leading to circulatory disturbances and function of kidneys). There are clinical symptoms of an intoxication in the form of abaissement of hair, nail plates. Occurrence of a multisystem lesion (a liver, lungs as a pneumonia noted in of cases, kidneys up to acute tubular necrosises) is possible. The grave condition of the patient, besides the expressed dehydration and disturbance purchase tegretol of electrolytic balance, is shown mainly by a syndrome of an endogenous intoxication which is caused by disturbance of a metabolism of fibers and a proteolysis. In this connection in liquid mediums of an organism there is an accumulation middlemolecular (SM), in 2-4 times exceeding norm.
They are made by so-called uremic fractions of fibers with molecular mass 500-5000 , and also with even larger molecular mass. In blood sharp increase of a leukocytic index of an intoxication is observed.