четверг, 6 ноября 2008 г.

The Latin term “placebo”

The Latin term “placebo” means to "like", “to give pleasure”. In medicine represents the indifferent substance used at a scientific estimation of action of medicines (under the pretext of a new preparation). The favorable effect плацебо is bound to psychological action on the patient. In clinical practice sometimes prescribe the patient with superficial disturbances of the mentality, wrongly considering, that symptoms of their illness have an organic basis. Плацебо it is possible to prescribe and the incurable patient for rising of their mood. The doctor should understand, that its relation to order ultram 200mg treatment influences result: the enthusiasm and belief in success can strengthen therapeutic effect, scepticism, on the contrary, to weaken. The patient reacting to introduction , name . The persons reacting on , are inclined to trust in miracles, are socially active, are less ambitious and are self-confident, acutely feel the individuality and more , than not reacting on . To are sensitive about 35 % of patients with organic diseases and 40 % of patients with functional disorders.

Value of impression which is made on the patient by the doctor, well-known from history, by G.A.Zaharina's experience (1829-1897). This outstanding doctor used the following situation during consultations of well-founded patients. After survey the professor in loneliness in the special blacked out room considered the diagnosis and treatment. At this time in the house the full silence should remain. The impression of such consultation on the patient and its relatives was favorably reflected in results of treatment and allowed Grigory Antonovichu to achieve amazing successes.

Efficiency of new medicines usually compare with in comparable groups of patients on a sex, age, duration and gravity of disease. Treatment in both groups spend simultaneously double blind method. Thus not only the patient, but also the attending physician do not know, whether the patient the examinee receives a preparation or (the full information the third party has only). The double blind method allows to exclude influence of bias on results of treatment as the doctor not only cannot have psychological influence on the patient, but also insufficiently objectively estimate effect of therapy. Application not always is necessary, and sometimes and unethically, for example, when patients is inadmissible to deprive of effective treatment. At a tuberculosis sick groups of comparison receive most effective of already applied preparations. Use in controllable clinical tests always puts ethical problems before the doctor. Modern demands to carrying out of clinical tests - Good Clinical Practice (GCP) - include obligatory observance of ethical standards which besides the decision of ethical committee on test carrying out concerns and the informed consent of the patient. However the last as show some researches, can affect result of test. If at application the aggravation of symptoms becomes perceptible, the patient should be deduced from research or to translate on active treatment within the limits of the same test.

Platsebo-reactions are used for a long time in medicine. When the doctor or someone from relatives shows attention and care of the patient, to that becomes frequent better. This influence, undoubtedly, keeps the value and now, despite the big achievements of medicine though quite often frames deceptive impressions and illusions about efficiency of some new methods of treatment. The fast improvement coming at sick virus infection under the influence of an antibiotic can be an example of such illusions. The probability of effect always should be considered, when there is no full confidence of accuracy of the diagnosis. Such situation meets almost at half of patients in the general practice. So, in group of patients, at which convincing data for certain disease at the moment of the reference it is not taped, application in 80 % of cases has led to improvement.

In the majority of the developed countries after the Second World War the augmentation of number of persons with various mental disturbances and the painful implications bound to them is noted. At them the effect any treatment is often enough observed. There was even a term buy vpxl 200mg “temporarily dependent sick - patients for whom the fact of an occurring with the doctor and its survey is important, and also the prescription of any therapy. When parts of such patients it has been declared, that they do not demand treatment, the effect as a whole did not differ from that at patients by whom symptomatic therapy was spent. Apparently, at many such patients application can be more safe and even effective, than appointment of active agents. However more often doctors are not inclined to use , regarding such treatment as charlatanism.

The platsebo-effect can be called any contact of the doctor to the patient. The trust of the patient to the doctor depends not only on its words, but also from appearance, a dialogue manner, and also others in effect few the studied factors. Different people possess various ability to dialogue. Some consider, that on character and trustful doctors cure softer better, than categorical and sharp. The effect usually is absent at conservative people, suspicious and mistrustful. The most expressed effect observe at an injection way of introduction. It depends on appearance and colour of tablets. At research of analgetic effect of tablets depending on their colour it decreased in the following sequence: red, blue, green, yellow. As well as active medicines, can cause subjective collateral reactions - delicacy, a headache, dryness in a mouth, constipations, an impotency.

Research of the importance of so-called "positive" and "negative" consultations at patients with a functional pathology is carried out. In the first case to the patient said, that it does not have serious disease and in the near future to it it becomes better; in the second informed, that character of illness is not absolutely clear. In both groups one patient prescribed , to another a drug intake did not recommend. Recover came is much more often and faster in the first group of patients; in both groups there were no differences in effect of treatment between sick, receiving and not receiving any preparation. The conclusion is drawn, that in daily practice the platsebo-effect meets often enough and in many respects depends on the person of the doctor.

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